Course: Molecular Biology

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Course title Molecular Biology
Course code 3160/FAME1
Organizational form of instruction Lecture
Level of course Master
Year of study not specified
Semester Winter
Number of ECTS credits 2
Language of instruction English
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Renčiuk Daniel, Mgr. Ph.D.
  • Hošek Jan, RNDr. Ph.D.
  • Brázdová Marie, Mgr. Ph.D.
Course content
1) Molecular biology and its position in biological sciences, milestones, personalities, central dogma of molecular biology 2) Information macromolecules, their structure, function and interaction in gene expression, genetic code. 3) Structure of prokaryotic genome, replication and gene expression in prokaryotes. 4) Structure of eukaryotic genome, replication and gene expression in eukaryotes. 5) Regulation of gene expression, molecular signalling. 6) RNA interference 7) Molecular biology of viruses, replication, expression of bacterial and animal virus's genes. 8) Mutagenesis, spontaneous and induced mutation and reversion. 9) Molecular basis of recombination, recombinantion in genetics. 10) Transposons, mechanisms of transposition, retroelements, retroviruses. 11) Reparation and excision mechanisms. 12) Molecular basis of cancerogenesis, protooncogenes and oncogenes, suppressor genes, oncoviruses. 13) Molecular evolution, origin of life on Earth.

Learning activities and teaching methods
unspecified
  • unspecified - 10 hours per semester
  • unspecified - 24 hours per semester
  • unspecified - 24 hours per semester
Learning outcomes
The aim of this subject is to provide students with basic information from molecular biology. The ground of lectures is focused on structure of proteins and nucleic acids and functions and relationships of these informational macromolecules in transition of genetic information. Students will familiarise with structure of prokaryotic and eukaryotic genomes, with mechanisms of replication, transcription, translation and regulation of gene expression. The molecular mechanisms of mutagenesis, recombination and transposition, reparation mechanisms and molecular basis of carcinogenesis are explained. The fundament of molecular evolution and theory of life origin on Earth are illustrated. Part of the lectures is focused on molecular biology methods and on applications of molecular biology principles in microbiology, pharmacology, human genetics, epidemiology and epizootology.

Prerequisites
unspecified

Assessment methods and criteria
unspecified
The examof two parts: writen tst (student has to obtain at least 60% of credits) and oral examination
Recommended literature
  • BARTOŠ, M., BARTOŠOVÁ, L. Základy molekulární biologie pro farmaceuty. FaF VFU Brno, 2006.
  • ROSYPAL, S. et al. Terminologie molekulární biologie. Vydavatel prof. RNDr. Stanislav Rosypal, DrSc., Brno., 2001.
  • ROSYPAL, S. et al. Úvod do molekulární biologie. Vydavatel prof. RNDR. Stanislav Rosypal, DrSc. Brno., 2002.
  • RUSSELL, P.J. iGenetics, A molecular Approach.. Pearson, Benjamin Cummings. New York, U.S.A., 2006.
  • WATSON, D.J. et al. Molecular biology of the gene. Cold Spring Harbor Laboratory Press, Pearson, Benjamin Cummings. New York, U.S.A, 2004.


Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Pharmacy - (12) Pharmaceutical sciences 2 Winter
Faculty of Pharmacy Pharmacy (1) Pharmaceutical sciences 2 Winter