Course: Human Physiology and Pathophysiology I

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Course title Human Physiology and Pathophysiology I
Course code 3140/F1PC1
Organizational form of instruction Lecture + Lesson
Level of course Master
Year of study not specified
Semester Winter
Number of ECTS credits 4
Language of instruction Czech
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
  • Feit Josef, Doc. MUDr. Ph.D.
  • Kauerová Tereza, PharmDr.
  • Kružicová Alžběta, Mgr.
  • Vítovec Jiří, Prof. MUDr. CSc.
  • Parák Tomáš, MUDr. Ph.D.
  • Suchý Pavel, Doc. MVDr. Ph.D.
  • Paráková Lenka, PharmDr. Ph.D.
  • Kotolová Hana, PharmDr. Ph.D.
  • Keltošová Stanislava, Mgr. Ing.
  • Hložková Jana, MVDr. Ph.D.
  • Scheer Peter, MVDr. Ph.D.
Course content
PATHOPHYSIOLOGY I LECTURES 1. General physiological principles. Cell physiology. Function of cell membrane and intracellular structures. Basic principles of physiological regulation. 2. Introduction into pathophysiology, symptoms of diseases and their diagnosing. Disease development. Genetic factors in pathogenesis. 3. Nonspecific defence mechanisms. Inflammation. Stress. Damage of organism (physical, chemical and biological) 4. Specific defensive mechanisms and their disorders. Cell-mediated and antibody immunity. White blood cells, functions and disorders. 5. Physiology of the locomotive apparatus. Most common diseases of bones, muscles and joints. Inflammatory and degenerative rheumatic diseases. 6. Physiology of digestion and absorption, metabolism of sugars, fats and proteins. Nutritional disorders ? obesity and starving. Metabolic syndrome. 7. Vitamins, mineral substances and trace elements. Hyper and hypovitaminoses. Diseases of deficiency and excess of mineral substances and trace elements. 8. Physiology of blood formation. Differential diagnosing of anaemia. 9. Hemostasis and hemocoagulation. Coagulation cascade and its disorders. Hemorrhagic and hypercoagulable states. 10. Physiology of the circulatory system. Formation and development of atherosclerosis. Ischemic heart disease. 11. Formation and transmission of excitement and its disorders. Inherited and acquired heart disorders. 12. Basic principles of the blood pressure regulation. Hypertensive disease. Hypotension. Circulation failure (shock). 13. Theory of the formation of malignant growth. Tumours and their classification. Overview of clinically most common cancers. Syllabus of exercises I. Blood I 1. Introduction into exercises, protocols processing, conditions for credit obtaining Red blood cells 2. Blood count 3. Erythrocytes count 4. Erythrocyte sedimentation 5. Hematocrit II. Blood II White blood cells ? immune system 1. Permanent blood smear and its staining 2. Differential leukocytes count 3. Phagocytary activity and leukocyte index III. Cardiovascular system 1. Auscultation of heart sounds 2. Measurement of blood pressure 3. Electrocardiography IV. Respiratory system 1. Auscultation of lungs 2. Spirometry 3. Pulse oxymetry V. Excretory system 1. Semi-quantitative urinalysis 2. Specific weight of urine 3. Kidney dilution ability VI. Reproductive system 1. Sperm quality evaluation 2. Menstrual cycle VII. Nervous system 1. Hearing tests 2. Eye tests 3. Optical illusions 4. EEG VIII. Obtaining credits

Learning activities and teaching methods
Learning outcomes
Human physiology is defined as a science of the functions of healthy organism at the level of cell, tissue, organ and organ systems. Pathophysiology is focused on etiopathogenesis - the mechanisms which lead from the primary cause via individual malfunctions to subsequent development of clinical symptoms of disease. Knowledge of these mechanisms serves to develop a suitable and efficient therapy and prevent resultant damage.


Assessment methods and criteria
In accordance with study and examining order of credit system of University of Veterinary and Pharmaceutical Sciences Brno.
Recommended literature
  • Fölsch U.R. et al. Patologická fyziologie. Praha Grada, 2003. ISBN 80-247-0319-X.
  • Trojan S. a kol. Lékařská fyziologie. Paraha . ISBN 9788071690368.
  • Vokurka Martin a kol. Patofyziologie pro nelékařské směry. UK Praha, 2014. ISBN 978-80-246-2032-9.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Pharmacy Pharmacy (1) Pharmaceutical sciences 2 Winter