Course: Medical Forms and Biopharmacy II

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Course title Medical Forms and Biopharmacy II
Course code 3130/FAFO2
Organizational form of instruction Lecture + Lesson
Level of course Master
Year of study not specified
Semester Summer
Number of ECTS credits 11
Language of instruction English
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Masteiková Ruta, Doc. PharmDr. CSc.
  • Kubová Kateřina, Doc. PharmDr. Ph.D.
  • Gajdziok Jan, Doc. PharmDr. Ph.D.
  • Smilková Ladislava, Mgr.
  • Franc Aleš, PharmDr. Ph.D.
  • Vysloužil Jakub, PharmDr. Ph.D.
  • Vetchý David, Doc. PharmDr. Ph.D.
Course content
Obligatory subject: MEDICAL FORMS AND BIOPHARMACY Summer semester Academic year: 2016/2017, term 8th, year 4th Extent: 9 hours per week Form: Lectures: 3 hours Practical training: 6 hours SYLLABUS OF LECTURES 1 16. 2. 2017 Dosage forms for rectal application. lecturer: Associate prof. Dr. Kateřina Kubová, Ph.D. 2 23. 2. 2017 Dosage forms for vaginal application. lecturer: Associate prof. Dr. Kateřina Kubová, Ph.D. 3 2. 3. 2017 Development of new drugs from galenical perspective lecturer: Dr. Aleš Franc, Ph. D. 4 9. 3. 2017 Pharmaceutical packaging. lecturer: Associated prof.Dr Jan Gajdziok, Ph.D. 5 16. 3. 2017 Pharmaceutical incompatibilities in dosage forms. lecturer: Associate prof. Dr. Kateřina Kubová, Ph.D. 6 23. 3. 2017 Granules, granulation methods. Evaluation of powders and granules. lecturer: Associated prof. Dr Jan Gajdziok, Ph.D 7 30. 3. 2017 Tablets, their production, and evaluation. lecturer: Dr. Aleš Franc, Ph.D. 8 6. 4. 2017 Coated products, their production and evaluation. lecturer: Associate prof. Dr. Jan Gajdziok, Ph.D 9 13 4. 2017 Oral dosage forms with controlled drug release. lecturer: Dr. Jakub Vysloužil, Ph.D. 10 20. 4. 2017 Good manufacturing practice in pharmacy lecturer: Dr. Aleš Franc, Ph. D. 11 27. 4. 2017 Validation in pharmaceutical technology lecturer: Dr. Aleš Franc, Ph.D. 12 4. 5. 2017 Pharmaceutical aerodispersions. lecturer: Associate prof. Dr. Jan Gajdziok, Ph.D 13 11. 5. 2017 Regulatory authorities evaluation of dosage forms lecturer: Associate prof. Dr. et Mgr. David Vetchý, Ph.D. 14 18. 5. 2017 Transdermal preparations, their production and evaluation. lecturer: Associate prof. Dr. Kateřina Kubová, Ph.D. SYLLABUS OF LABORATORY PRACTICE 16. 2. 2017 Ointments. Preparation and evaluation. 23. 2. 2017 Creams. Preparation and evaluation. 2. 3. 2017 Pastes and gels. Preparation and evaluation 9. 3. 2017 Rectal suppositories. Determination of base replacement coefficient, calculations, preparation of suppositories with known base replacement coefficient. 16. 3. 2017 Rectal suppositories. Experimental determination of base replacement coefficient. Preparation of suppositories with unknown base replacement coefficient. 23. 3. 2017 Vaginal dosage forms. Preparation and evaluation. 30. 3. 2017 Incompatibilities in liquid, semisolid and solid dosage forms. 6. 4. 2017 Calculations in pharmaceutical technology. Technological processes in preparation of difficult prescriptions. 13 4. 2017 Alternative training. 20. 4. 2017 Tablets preparation by direct compression. 27. 4. 2017 Fluid bed granulation method. 4. 5. 2017 Wet and melt granulations. 11. 5. 2017 Evaluation of solid dosage forms. 18. 5. 2017 Test and check training.

Learning activities and teaching methods
unspecified
Learning outcomes
One of the main obligatory pharmaceutical disciplines dealing with preparation, manufacturing and quality control of medicaments including technological procedures, equiment, excipients and appropriate analytical devices. It covers the influence of the application form on drug bioavailability.

Prerequisites
Obligatory subject: DOSAGE FORMS AND BIOPHARMACY Academic year: 2014/2015, term 8th, year 4th Extent: 9 hours per week Form: Lectures: 3 hours Practical training: 6 hours SYLLABUS OF LECTURES 1 Development of new drugs from galenical perspective lecturer: Dr. Aleš Franc, Ph. D. 2 Validation in pharmaceutical technology lecturer: Dr. Aleš Franc, Ph.D. 3 Semisolid dosage forms - creams, gels, pastes lecturer: Dr. Martina Kejdušová, Ph.D. 4 Dosage forms for rectal application. lecturer: Dr. Kateřina Dvořáčková, Ph.D. 5 Dosage forms for vaginal application. lecturer: Dr. Kateřina Dvořáčková, Ph.D. 6 Pharmaceutical incompatibilities in dosage forms. lecturer: Dr. Martina Kejdušová, Ph.D. 7 Tablets, their production, and evaluation. lecturer: Dr. Aleš Franc, Ph.D. 8 Coated products, their production and evaluation. lecturer: Dr. Jan Gajdziok, Ph.D 9 Capsules, their production and evaluation. lecturer: Dr. Kateřina Dvořáčková, Ph.D. 10 Oral dosage forms with controlled drug release. lecturer: Dr. Martina Kejdušová, Ph.D. 11 Regulatory authorities evaluation of dosage forms lecturer: Ass. Prof. David Vetchý, Ph.D. 12 Transdermal preparations, their production and evaluation. lecturer: Dr. Kateřina Dvořáčková, Ph.D. 13 Pharmaceutical aerodispersions. lecturer: Dr. Jan Gajdziok, Ph.D PRACTICAL TRAINING 1. Ointments. Preparation and evaluation. 2. Creams. Preparation and evaluation. 3. Pastes and gels. Preparation and evaluation 4. Rectal suppositories. Determination of base replacement coefficient, calculations, preparation of suppositories with known base replacement coefficient. 5. Rectal suppositories. Experimental determination of base replacement coefficient. Preparation of suppositories with unknown base replacement coefficient. 6. Vaginal dosage forms. Preparation and evaluation. 7. Incompatibilities in liquid, semisolid and solid dosage forms. 8. Calculations in pharmaceutical technology.Technological processes in preparation of difficult prescriptions. 9. Alternative training. 10. Tablets preparation by direct compression. 11. Fluid bed granulation method. 12. Wet and melt granulations. 13. Evaluation of solid dosage forms. 14. Test and check training.

Assessment methods and criteria
unspecified
Lectures are recommended due to the lack of appropriate literature. Practical training - compulsory. oral examination
Recommended literature
  • Česká a slovenská farmacie.
  • Český lékopis 2005, 1. - 3. díl. Grada Publishing, 2005.
  • Chalabala, M., Heinrich, J. Základy výroby a tvorby liekov. Osveta Martin, 1988.
  • Komárek, P., Rabišková, M. Technologie léků. Galén, Praha, 2006. ISBN 80-7262-423-7.
  • Zathurecký, L., Chalabala, M., Janků, I., Modr., Z. Biofarmácia a farmakokinetika. Osveta Martin, 1989. ISBN 80-217-0068-8.


Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Pharmacy - (12) Pharmaceutical sciences 4 Summer
Faculty of Pharmacy Pharmacy (1) Pharmaceutical sciences 4 Summer