Course: Toxicology

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Course title Toxicology
Course code 2390/VATX
Organizational form of instruction Lecture + Lesson
Level of course Master
Year of study not specified
Semester Winter
Number of ECTS credits 4
Language of instruction English
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Svobodová Zdeňka, prof. MVDr. DrSc.
  • Široká Zuzana, PharmDr. Ph.D.
Course content
LECTURES: 1. Specification of toxicology. Historical data. Toxicity assessment; 2. General toxicology fundamental; 3. Inorganic substances poisoning in animals (ammonia, urea, cyanides, fluorosis, carbon dioxide); 4. Organic substances poisoning in animals (metaldehyde, chlorinated hydrocarbons, tensides, methylxanthines); 5. Organic substances poisoning in animals (alcohols, phthalates, ethylene glycol, musc compounds); 6. Organic substances poisoning in animals (PCBs, dioxins, PAHs, cyanotoxins); 7. Toxic plant poisoning in animals - food toxins 1 (glucosides, glycoalkaloids); 8. Toxic plant poisoning in animals - food toxins 2 (glucosinolates, phytoestrogens); 9. Metal poisoning in animals (mercury, lead, cadmium); 10. Metal poisoning in animals (copper, zinc, arsenic, tin, selenium, iron, thallium); 11. Drug poisoning in animals; 12. Pesticide poisoning in animals (pyrethroid, triazine and diazine-based pesticides); 13. Pesticide poisoning in animals (bipyridil and metal-based pesticides). PRACTICAL WORKS: 1. Security of work. Introduction to practical work in toxicology. Local investigation. Sampling for chemical-toxicological analysis. System of toxicological laboratory examination; 2. Feeding salt poisoning. NaCl determination in liver and in feed. Chloride determination in water; 3. Nitrogenous compounds poisoning and diagnostics. Methaemoglobin determination in blood. Nitrate and nitrite determination in feed water. Carbon monoxide poisoning. Carbonylhaemoglobin determination in blood; 4. Insecticide poisoning and diagnostics. Chlorinated insecticide determination. Organophosphate, carbamate and pyrethroid action. Plasma cholinesterase determination; 5. Rodenticide poisoning and diagnostics. Anticoagulants determination; 6. Mycotoxin poisoning and diagnostics. Test; 7. Phytotoxin poisoning and diagnostics. Orientation precipitating reaction. Case study submission; 8. Toxicity tests according to OECD; 9. Rape poisoning, zootoxin poisoning, botulism; 10. Fish poisoning. Water analysis, biological toxicity test; 11. Most frequent poisoning of bees, credit test; 12. Case studies solution; 13. Case studies solution + credit.

Learning activities and teaching methods
unspecified
Learning outcomes
Objective of study of the toxicology subject is completely to master general principles of toxic substances effects, methods of toxicity assessment, mechanisms of action of individual toxicants, clinical and pathological manifestation of poisonings, diagnostics and therapy of the poisonings and preventive measures. Attention shall be concentrated above all to poisonings and animal health impairments due to feed contamination caused first of all by residues of pesticides, mycotoxins, phytotoxins and in same cases also poisonings caused by misplacement of feed additives. Case studies of poisonings shall be utilized for study purposes.

Prerequisites
unspecified

Assessment methods and criteria
unspecified
100% attendance on practical works; pass 2 tests; preparation and presentation of a case study. Only for students of 3rd study year.
Recommended literature
  • PLUMLEE, K. H. et al:. Clinical Veterinary Toxicology. Mosby St. Louis, 2003, 477 p..


Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Veterinary Medicine Veterinary Medicine (12) Veterinary medicine and veterinary prevention 3 Winter
Faculty of Veterinary Medicine Veterinary Medicine (1) Veterinary medicine and veterinary prevention 3 Winter